Mark Kelley and his colleagues wanted to know more about "chemo brain," a phenomenon that affects about half of all cancer patients. Its symptoms include loss of memory or cognitive function, and tingling in the hands and feet. Sometimes the effects are so serious cancer patients stop treatment altogether even though it might be successfully combating their cancer. In researching this phenomenon Dr. Kelley and his colleagues realized another challenge - they did not know what other researchers at IUPUI as well as other institutions were learning about "chemo brain."
This inspired Dr. Kelley to apply the Six Sigma total quality management business model to allow investigators to better organize their research efforts and stay more focused on their work. The result is the IU Simon Cancer Center Translational Research Acceleration Collaboration (ITRAC). So far over 70 projects have a "map" as a result of the ITRAC process. By bringing together researchers who otherwise might not have worked together, ITRAC reduces "silo-based research," offers new perspectives on research, and identifies potential bottlenecks. This model offers the potential to better utilize resources through collaboration and sharing of ideas and equipment as well as successfully accessing funding for their work.
Professor Kelley's application of a business model to support research planning and implementation is another example of how IUPUI's faculty members are TRANSLATING their RESEARCH INTO PRACTICE.
Selected Publications in IUPUIScholarWorks
With over fifty scholarly articles contributed to IUPUI's free, open access repository, Dr. Kelley has made research knowledge about the role of the DNA repair enzyme APE1/Ref-1 in cancer therapy available available to researchers, students and readers around the world.
Li, Y., Liu, X., Zhou, T., Kelley, M. R., Edwards, P., Gao, H., & Qiao, X. (2014). Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization. Redox Biology, 2, 485-494. Available from: http://hdl.handle.net/1805/4698
Kelley, M. R., Georgiadis, M. M., & Fishel, M. L. (2012). APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. Current Molecular Pharmacology, 5(1), 36. Available from: http://hdl.handle.net/1805/4688
Kelley, M. R. (2011). DNA repair inhibitors: Where do we go from here?. DNA Repair, 10(11), 1183. Available from: http://hdl.handle.net/1805/4687
Fishel, M. L., Jiang, Y., Rajeshkumar, N. V., Scandura, G., Sinn, A. L., He, Y., ... & Kelley, M. R. (2011). Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth. Molecular Cancer Therapeutics, 10(9), 1698-1708. Available from: http://hdl.handle.net/1805/4685
Vasko, M. R., Guo, C., Thompson, E. L., & Kelley, M. R. (2011). The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation. DNA Repair, 10(9), 942-952. Available from: http://hdl.handle.net/1805/4686
Kelley, M. R., Luo, M., Reed, A., Su, D., Delaplane, S., Borch, R. F., ... & Georgiadis, M. M. (2011). Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. Antioxidants & Redox Signaling, 14(8), 1387-1401. Available from: http://hdl.handle.net/1805/4867
Jiang, Y., Guo, C., Fishel, M. L., Wang, Z. Y., Vasko, M. R., & Kelley, M. R. (2009). Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. DNA repair, 8(11), 1273-1282. Available from: http://hdl.handle.net/1805/4814
Tell, G., Quadrifoglio, F., Tiribelli, C., & Kelley, M. R. (2009). The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxidants & Redox Signaling, 11(3), 601-619. Available from: http://hdl.handle.net/1805/4803
Bapat, A., Fishel, M. L., & Kelley, M. R. (2009). Going ape as an approach to cancer therapeutics. Antioxidants & redox signaling, 11(3), 651-667. Available from: http://hdl.handle.net/1805/4789
Reed, A. M., Fishel, M. L., & Kelley, M. R. (2009). Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation. Future Oncology, 5(5), 713-726. Available from: http://hdl.handle.net/1805/4819
Find more free articles by Mark R. Kelley in IUPUIScholarWorks.