Featured Scholar


Jeffrey A. Kline, IUPUI Translational Scholar

Featured Scholar : Jeffrey A. Kline, MD

Professor of Emergency Medicine
Professor of Physiology
Vice Chair, Research
Department of Emergency Medicine, IU School of Medicine
ude[dot]ui[at]enilkfej


Facial Expression as a Diagnostic Tool for Pulmonary Embolism

Jeffrey Kline studies blood clots, the people they affect, and the providers who care for those people. His diagnostic research interests focus on human affect analysis, pretest probability, and novel breath-based instruments to reduce medical imaging. His human treatment research includes randomized trials of fibrinolysis and inhaled nitric oxide to reduce heart damage from blood clots in the lungs. He derived and validated a decision rule to help emergency physicians reduce unnecessary diagnostic tests for low-risk patients with symptoms of blood clots in the lungs.

Dr. Kline’s current work focuses on using the human face as a diagnostic instrument to further help doctors make informed decisions about diagnostic testing for blood clots. His laboratory work focuses on mechanisms and treatment of acute pulmonary hypertension from pulmonary embolism (PE), animal models of pulmonary embolism, and a nanoparticle-delivered enzyme, plasmin, to promote clot lysis without increasing risk. He helped set up an advanced hospital treatment program to treat patients with severe PE, and he also created and runs a clinic specifically to allow patients diagnosed with blood clots in the emergency department to treat themselves at home, rather than in the hospital.

Dr. Kline’s work using the human face as a diagnostic instrument is another example of how IUPUI’s faculty members are TRANSLATING their RESEARCH INTO PRACTICE.

Selected Publications in IUPUI ScholarWorks

With over fifty research papers contributed to IUPUI's free, open access repository, Dr. Kline has made translational research knowledge available to health professionals, researchers, students and patients around the world.

Insenser M, Montes-Nieto R, Martínez-García MÁ, Durán EF, Santiuste C, Gómez V, Kline JA, et al. Identification of Reduced Circulating Haptoglobin Concentration as a Biomarker of the Severity of Pulmonary Embolism: A Nontargeted Proteomic Study. PLoS ONE. 2014 Jun 30;9(6):e100902. Available from: http://hdl.handle.net/1805/4881

Diercks DB, Owen KP, Tolstikov V, Sutter ME, Kline JA. Urinary Metabolomic Analysis to Detect Changes After Intravenous, Non-ionic, Low Osmolar Iodinated Radiocontrast for Computerized Tomographic Imaging. Western Journal of Emergency Medicine. 2014 Jan 1;15(2). Available from: http://hdl.handle.net/1805/4880

Anderson RT, Montori VM, Shah ND, Ting HH, Pencille LJ, Demers M, Kline JA, et al. Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial. Trials. 2014 May 10;15(1):166. Available from: http://hdl.handle.net/1805/4879

Sterling SA, Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Summers RL, et al. Characteristics and Outcomes of Patients with Vasoplegic Versus Tissue Dysoxic Septic Shock. Shock. 2013 Jul;40(1):11–4. Available from: http://hdl.handle.net/1805/4886

Self WH, Courtney DM, McNaughton CD, Wunderink RG, Kline JA. High Discordance of Chest X-ray and CT for Detection of Pulmonary Opacities in ED Patients: Implications for Diagnosing Pneumonia. Am J Emerg Med. 2013 Feb;31(2):401–5. Available from: http://hdl.handle.net/1805/4885

Mitchell AM, Jones AE, Tumlin JA, Kline JA. 1−Year Mortality Following Contrast−Induced Nephropathy. American Journal of Internal Medicine. 2013;1(1):1-6. Available from: http://hdl.handle.net/1805/4893

Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Jones AE. Plasma Levels of Mitochondrial DNA in Patients Presenting to the Emergency Department with Sepsis. Shock. 2012 Oct;38(4):337–40. Available from: http://hdl.handle.net/1805/4895

Venkatesh AK, Kline JA, Courtney DM, Camargo CA, Plewa MC, Nordenholz KE, et al. Evaluation of Pulmonary Embolism in the Emergency Department and Consistency With a National Quality Measure. Arch Intern Med. 2012 Jul 9;172(13):1028–32. Available from: http://hdl.handle.net/1805/4896

Than M, Cullen L, Aldous S, Parsonage WA, Reid CM, Greenslade J, ... Kline JA, et al. 2-Hour Accelerated Diagnostic Protocol to Assess Patients With Chest Pain Symptoms Using Contemporary Troponins as the Only Biomarker: The ADAPT Trial. Journal of the American College of Cardiology. 2012 Jun 5;59(23):2091–8. Available from: http://hdl.handle.net/1805/4892

Kline JA, Roy P-M, Than MP, Hernandez J, Courtney DM, Jones AE, et al. Derivation and validation of a multivariate model to predict mortality from pulmonary embolism with cancer: the POMPE-C tool. Thromb Res. 2012 May;129(5):e194–9. Available from:  http://hdl.handle.net/1805/4894

Find more free, translational articles by Jeffrey A. Kline in IUPUIScholarWorks.