My research focuses on social processes promoting youth anti-drug socialization. This work attempts to merge the health promotion literature on family communication with that focusing on media. By integrating social cognitive theory, narrative engagement theory, primary socialization theory, and general theory of family communication into a theoretical framework, my research tests the effects of entertainment education (E-E) videos and parent- adolescent communication about media portrayals of substance use on youth’s substance use behaviors. To test the entertainment-education video effects, I used the evidence-based, school-based intervention for youth substance use prevention, titled keep' it REAL (kiR) program, which was proven to be effective and listed as an evidenced based intervention on the National Registry of Evidence-based Programs and Practices (NREPP). My research on kiR E-E videos found then effective in influencing youth refusal self-efficacy and their recent substance use behaviors. My research is conducted by interdisciplinary research team members consisting of scholars in the field of biobehavioral health, human development and family studies, and communication studies. Due to the nature of interdisciplinary research, my research was presented at American Psychological Association conference and awarded by National Institute of Drug Abuse. My research is goal is to prevent youth from substance use and abuse. E-E videos teach communicative, drug resistance strategies to refuse drug offers. My research also encourages parent-adolescent communication about substance use in which a parent serves as anti-drug socialization agent for youth substance use.