IUPUI is Indiana's premier urban research university. The campus enrolls more than 30,000 students in 21 schools and academic units.
Bonnie Blazer-Yost
Professor
Biology Cellular and Integrative Biology Anatomy and Cell Biology
bblazer@iupui.edu
Investigation of new treatments for polycystic kidney disease
We are using animal models to study whether a class of FDA-approved drugs could be used for the treatment of polycystic kidney disease (PKD). PKD is a relatively common genetic disease that leads to kidney failure. Our studies are based on a series of unrelated experiments that serendipitously showed that some of the disease pathology in PKD may be amenable to treatment with insulin sensitizing agents that are used to treat type 2 diabetes in humans. These drugs have relatively few side effects and, therefore, they would be ideal treatment options for long-term therapy in PKD.
