Featured Scholar: Jay L. Hess, MD
Vice President for University Clinical Affairs, Dean of the IU School of Medicine
Identifying and Treating Leukemia
Jay L. Hess has worked in early stage drug discovery in academia and in establishing sequencing-based diagnostics to improve care for cancer patients. A board-certified Hematopathologist and author of more than 100 scientific papers and book chapters, Dr. Hess is considered one of the nation’s leaders in the epigenetics of leukemia. He continues to run an active NIH-funded research laboratory.
Dr. Hess became the 10th Dean of the IU School of Medicine (IUSM) and Vice President for University Clinical Affairs at Indiana University on September 1st, 2013. He joined IUSM after eight years at the University of Michigan, where he advanced the causes of translational research, pathology informatics and sequencing-based diagnostics.
While at Michigan, Dr. Hess helped establish the Michigan Center for Translational Pathology, created one of the first pathology informatics divisions in the nation and led the University of Michigan Health Care System strategy implementation in personalized medicine. In 2012, he co-founded and chaired the board of directors for Paradigm, a sequencing-based not-for-profit diagnostics company that provides next generation sequencing and data analysis to improve care for cancer patients.
Dr. Hess’s work to address bottlenecks in clinical translation of more targeted and effective therapies is another example of how IUPUI’s faculty members are TRANSLATING their RESEARCH INTO PRACTICE.
Selected Publications in IUPUI ScholarWorks
With several research works contributed to IUPUI's free, open access repository, Dr. Hess has made translational research knowledge available to professionals, researchers, students, and communities around the world.
Borkin, D., He, S., Miao, H., Kempinska, K., Pollock, J., Chase, J., … Grembecka, J. (2015). Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell, 27(4), 589–602. http://hdl.handle.net/1805/10960
Cao, F., Townsend, E. C., Karatas, H., Xu, J., Li, L., Lee, S., … Dou, Y. (2014). Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia. Molecular Cell, 53(2), 247–261. http://hdl.handle.net/1805/9243
Collins, C., Wang, J., Miao, H., Bronstein, J., Nawer, H., Xu, T., … Hess, J. L. (2014). C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proceedings of the National Academy of Sciences of the United States of America, 111(27), 9899–9904. http://hdl.handle.net/1805/8544