Featured Scholar: Christie Orschell, Ph.D.
Department of Medicine
School of Medicine
Side effects of cancer chemotherapy and radiotherapy include destruction of bone marrow stem and progenitor cells. These cells help the body fight against life-threatening infection and hemorrhage. Exposure from radiological terrorism or accidents also leads to severe bone marrow damage. There are many FDA-approved medications to help bone marrow recovery after cancer treatment, but currently only two approved medical countermeasures (MCM) for individuals exposed to lethal doses of radiation. These medications, Neupogen and Neulasta, are “repurposed” from the cancer field.
Dr. Christie Orschell’s laboratory developed mouse models of the Hematopoietic-Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE) for efficacy testing of MCM against radiation according to the FDA Animal Rule. Under the Animal Rule, which guides drug development when human efficacy studies are unethical or unfeasible, development of radiation MCMs must first use animal models. Her models contributed to the approval of Neupogen and Neulasta, and have been promoted by the NIH to undergo qualification as a “drug development tool” by the FDA, which would allow the model to be publicly available for use in drug development programs and included in FDA submissions without the need to reconfirm suitability of the model.
Dr. Orschell’s work to develop animal models for radiation drug discovery is another example of how IUPUI faculty are TRANSLATING RESEARCH INTO PRACTICE.
Selected Publications in IUPUI ScholarWorks
With several research works contributed to IUPUI's free, open access repository, Dr. Orschell has made translational research knowledge available to professionals, researchers, students, and communities around the world.
Beatrice Thungu, Miguel Ortiz, Joseph L. Unthank, Christie M. Orschell, and Steven J. Miller. 2016 April 8. Delayed effects of acute radiation exposure on the cardiovascular system using a murine model of the hematopoietic acute radiation syndrome. Poster session presented at IUPUI Research Day 2016, Indianapolis, Indiana. http://hdl.handle.net/1805/9541
Shinha, T., Mi, D., Liu, Z., Orschell, C. M., Lederman, M. M., & Gupta, S. K. (2015). Relationships Between Renal Parameters and Serum and Urine Markers of Inflammation in Those With and Without HIV Infection. AIDS Research and Human Retroviruses, 31(4), 375–383. http://hdl.handle.net/1805/10678
Quickery, A., Unthank, J. L., Miller, S. J., Orschell, C. M. (2015, April 17). Delayed effects of acute radiation exposure (DEARE) in a murine model of the hematopoietic acute radiation syndrome: Multiple-organ injury consequent to total body irradiation. Poster session presented at IUPUI Research Day 2015, Indianapolis, Indiana. http://hdl.handle.net/1805/6259
Nelson, R. P., Khawaja, M. R., Perkins, S. M., Elmore, L., Mumaw, C. L., Orschell, C., & Paczesny, S. (2014). Prognostic Biomarkers for Acute Graft-Versus-Host-Disease Risk following Cyclophosphamide-Fludarabine Nonmyeloablative Allotransplantation. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 20(11), 1861–1864. http://hdl.handle.net/1805/11319
Chua, H. L., Plett, P. A., Sampson, C. H., Katz, B. P., Carnathan, G. W., MacVittie, T. J., … Orschell, C. M. (2014). SURVIVAL EFFICACY OF THE PEGYLATED G-CSFS MAXY-G34 AND NEULASTA IN A MOUSE MODEL OF LETHAL H-ARS, AND RESIDUAL BONE MARROW DAMAGE IN TREATED SURVIVORS. Health Physics, 106(1), 10.1097/HP.0b013e3182a4df10. http://hdl.handle.net/1805/9011
Plett, P. A., Chua, H. L., Sampson, C. H., Katz, B. P., Fam, C. M., Anderson, L. J., … Orschell, C. M. (2014). PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the Hematopoietic Syndrome of the Acute Radiation Syndrome. Health Physics, 106(1), 10.1097/HP.0b013e3182a4dd4e. http://hdl.handle.net/1805/9001
Spencer, Cleandrea, Hui Lin Chua, Arthur Plett, Carol Sampson, Mandar Joshi, Christopher S. Roberts, Kelsey Lipking, Christie M. Orschell, and George E. Sandusky. Increased Incidence of Lymphosarcoma in Long-Term Murine Survivors of Lethal Radiation: A Classification of Subtypes. Poster session presented at IUPUI Research Day 2013, Indianapolis, Indiana. http://hdl.handle.net/1805/7182
Orschell, C. M., Borneo, J., Munugalavadla, V., Ma, P., Sims, E., Ramdas, B., … Kapur, R. (2008). Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells. Experimental Hematology, 36(5), 655–666. http://hdl.handle.net/1805/8160