Featured Scholar: Sunil Badve, MBBS, MD (Path), FRCPath (Engl)
Associate Professor, IU School of Medicine
IU Simon Cancer Center
Indiana Center for Systems Biology and Personalized Medicine
Sunil Badve's translational research efforts on efficient treatment of breast cancer have a two-pronged approach; developing novel targeted therapies on the one hand and identifying ineffective therapies on the other. His team is studying the individual biological components that culminate in cancer. Gaining a better understanding of these molecular mechanisms will enable identification of key "nodes" in cellular pathways, which can then be targeted by biological agents leading to better diagnosis and effective treatment of breast cancer.
Dr. Badve demonstrated that the FoxA1 protein plays a critical role in determining responses to anti-hormonal therapy IU patent, being licensed. His group has developed a gene signature useful for predicting brain metastasis (IU patent pending) and is currently, with (IU and non-IU) collaborators, trying to dissect the pathways associated with brain metastasis with the hope of preventing and treating this disease. He is also collaborating with IU and Purdue researchers to develop novel methods of detecting and treating breast cancer.
Dr. Badve's practical application of research into information that can be used by local clinicians in treating breast cancer is another example of how IUPUI's faculty members are TRANSLATING their RESEARCH INTO PRACTICE.
Selected Publications in IUPUI ScholarWorks
With several research works contributed to IUPUI's free, open access repository, Dr. Badve has made translational research knowledge available to professionals, researchers, students, and communities around the world.
Buechler, S. A., Gökmen-Polar, Y., & Badve, S. S. (2018). EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor–Positive Breast Cancer. Clinical breast cancer. http://hdl.handle.net/1805/17274
Rakha, E. A., Miligy, I., Gorringe, K. L., Toss, M. S., Green, A. R., Fox, S. B., Schmitt, F. C., Tan, P.-H., Tse, G. M., Badve, S., Decker, T., Vincent-Salomon, A., Dabbs, D. J., Foschini, M. P., Moreno, F., Wentao, Y., Geyer, F. C., Reis-Filho, J. S., Pinder, S. E., Lakhani, S. R. and Ellis, I. O. (2018), Invasion in breast lesions: the role of the epithelial-stroma barrier. Histopathology. Accepted Author Manuscript. http://hdl.handle.net/1805/15076
Suarez, C. D., Wu, J., Badve, S. S., Sparano, J. A., Kaliney, W., & Littlepage, L. E. (2017). The AKT inhibitor triciribine in combination with paclitaxel has order-specific efficacy against Zfp217-induced breast cancer chemoresistance. Oncotarget, 8(65), 108534–108547. http://hdl.handle.net/1805/16378
Padda, S. K., Yao, X., Antonicelli, A., Riess, J. W., Shang, Y., Shrager, J. B., … Badve, S. S. (2017). Paraneoplastic Syndromes and Thymic Malignancies: An Examination of the International Thymic Malignancy Interest Group Retrospective Database. Journal of Thoracic Oncology. http://hdl.handle.net/1805/14964
Kim, J., Geyer, F. C., Martelotto, L. G., Ng, C. K. Y., Lim, R. S., Selenica, P., Li, A., Pareja, F., Fusco, N., Edelweiss, M., Kumar, R., Gularte-Merida, R., Forbes, A. N., Khurana, E., Mariani, O., Badve, S., Vincent-Salomon, A., Norton, L., Reis-Filho, J. S. and Weigelt, B. (2017), MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene. J. Pathol.. Accepted Author Manuscript. http://hdl.handle.net/1805/14916
Rakha, E. A., Badve, S., Eusebi, V., Reis-Filho, J. S., Fox, S. B., Dabbs, D. J., … Ellis, I. O. (2016). Breast lesions of uncertain malignant nature and limited metastatic potential: Proposals to improve their recognition and clinical management. Histopathology, 68(1), 45–56. http://hdl.handle.net/1805/12850
Bhat-Nakshatri, P., Goswami, C. P., Badve, S., Magnani, L., Lupien, M., & Nakshatri, H. (2016). Molecular Insights of Pathways Resulting From Two Common PIK3CA Mutations in Breast Cancer. Cancer Research, canres.3174.2015. http://hdl.handle.net/1805/11964
Gökmen-Polar, Y., Kesler, K., Loehrer, P. J., & Badve, S. (2016). NUT Midline Carcinoma Masquerading As a Thymic Carcinoma. Journal of Clinical Oncology, 34(14), e126–e129. http://hdl.handle.net/1805/11799
Liu, J., Damayanti, N. P., Cho, I.-H., Polar, Y., Badve, S., & Irudayaraj, J. M. K. (2015). Single-cell screening and quantification of transcripts in cancer tissues by second-harmonic generation microscopy. Journal of Biomedical Optics, 20(9), 096016. http://hdl.handle.net/1805/12621
Nakshatri, H., Appaiah, H. N., Anjanappa, M., Gilley, D., Tanaka, H., Badve, S., … Bhat-Nakshatri, P. (2015). NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death & Disease, 6(1), e1608–. http://hdl.handle.net/1805/11437
Burnett, R. M., Craven, K. E., Krishnamurthy, P., Goswami, C. P., Badve, S., Crooks, P., … Nakshatri, H. (2015). Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget, 6(14), 12682–12696. http://hdl.handle.net/1805/10369
Provenzano, E., Bossuyt, V., Viale, G., Cameron, D., Badve, S., Denkert, C., … Symmans, W. F. (2015). Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group. Modern Pathology, 28(9), 1185–1201. http://hdl.handle.net/1805/9029
Duchnowska, R., Jassem, J., Goswami, C. P., Dundar, M., Gökmen-Polar, Y., Li, L., … Badve, S. (2015). Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients. Journal of Neuro-Oncology, 122(1), 205–216. http://hdl.handle.net/1805/8899
Westphal, S. M., Jani, M., & Badve, S. (2010). Breast calcifications following electrical defibrillation: An unusual mammographic appearance. Radiology Case Reports, 5(2), 346. http://hdl.handle.net/1805/12187