Featured Scholar: Sophie Paczesny, MD, PhD
Translating Novel Biomarkers of Transplant Immunity and Tolerance
Allogeneic hematopoietic stem cell transplantation (HSCT) is a major therapy for malignant diseases of the blood and bone marrow and the most potent form of immune therapy against these diseases through its graft-versus-leukemia/tumor (GVL/GVT) effect. However, the efficacy of allogeneic HSCT has been impeded by frequent and severe graft-versus- host disease (GVHD) that is tightly linked to the GVL/GVT effect. Both acute and chronic forms of GVHD exist. The immunology of GVHD and GVL responses are complex and cytokines and cellular effectors are critical. Dr. Paczesy’s laboratory focuses on understanding the role of cytokines and cellular effectors in the biology of GVHD/GVL by discovering and investigating biomarkers in the blood and tissue of patients following allogeneic HSCT.
The goal of Dr. Paczesy’s laboratory is to develop tests to predict the risk of developing CVHD, responsiveness to treatment, and patient survival by integrating both proteomic and cellular biomarkers for the diagnosis and prognosis of GVHD. They are interested in both acute and chronic GVHD, which has overlapping features of immunodeficiency and symptoms of naturally occurring autoimmune disorders. Indeed, a prominent clinical feature of chronic GVHD is a debilitating fibrosing skin disease whose gross and histologic features resemble scleroderma (SSc) and, less commonly, morphea. Because of these potential biological similarities between chronic GVHD and autoimmune diseases, her work is also relevant.
Dr. Paczesy’s work to predict the risk of developing CVHD is another example of how IUPUI faculty are TRANSLATING RESEARCH INTO PRACTICE.
Selected Publications in IUPUI ScholarWorks
With several research works contributed to IUPUI's free, open access repository, Dr. Paczesy has made translational research knowledge available to professionals, researchers, students, and communities around the world.
Akil, A., Zhang, Q., Mumaw, C. L., Raiker, N., Yu, J., Velez de Mendizabal, N., … Paczesny, S. (2015). Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 21(10), 1739–1745. http://hdl.handle.net/1805/11572
Ramadan, A., & Paczesny, S. (2015). Various Forms of Tissue Damage and Danger Signals Following Hematopoietic Stem-Cell Transplantation. Frontiers in Immunology, 6, 14. http://hdl.handle.net/1805/10051
Gleimer, M., Li, Y., Chang, L., Paczesny, S., Hanauer, D. A., Frame, D. G., … Choi, S. W. (2015). Baseline body mass index among children and adults undergoing allogeneic hematopoietic cell transplantation: clinical characteristics and outcomes. Bone Marrow Transplantation, 50(3), 402–410. http://hdl.handle.net/1805/8666
Paczesny, S., Hakim, F. T., Pidala, J., Cooke, K., Lathrop, J., Griffith, L. M., … Schultz, K. R. (2015). National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease: III. The 2014 Biomarker Working Group Report. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 21(5), 780–792. http://hdl.handle.net/1805/8606
Nelson, R. P., Khawaja, M. R., Perkins, S. M., Elmore, L., Mumaw, C. L., Orschell, C., & Paczesny, S. (2014). Prognostic Biomarkers for Acute Graft-Versus-Host-Disease Risk following Cyclophosphamide-Fludarabine Nonmyeloablative Allotransplantation. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 20(11), 1861–1864. http://hdl.handle.net/1805/11319
Paczesny, S., Duncan, C., Jacobsohn, D., Krance, R., Leung, K., Carpenter, P., … Cooke, K. (2014). Opportunities and Challenges of Proteomics in Pediatric Patients: Circulating Biomarkers After Hematopoietic Stem Cell Transplantation As a Successful Example. Proteomics. Clinical Applications, 8(0), 837–850. http://hdl.handle.net/1805/7565