Featured Scholar: Harikrishna Nakshatri, PhD, BVSc
Marian J. Morrison Professor, Breast Cancer Research, IU School of Medicine
Professor of Surgery and
Professor of Biochemistry & Molecular Biology
Enhancing Hormone Therapy and Chemotherapy Sensitivity of Breast Cancer
Breast cancers are broadly classified into estrogen receptor positive (ER+) and estrogen receptor negative (ER-) subtypes. Anti-estrogens (hormone therapy) and chemotherapy are treatment options for ER+ and ER- breast cancers, respectively. However, resistance to therapies is very common, and disease recurrence is associated with the spread of the diseases to multiple organs (metastasis). Dr. Nakshatri's research lab focuses on mechanisms of resistance to anti-estrogens and chemotherapy, predicting therapy resistance at the time of diagnosis, and developing effective combination therapies, particularly for metastasis.
His group has identified and commercialized biomarkers that may predict response to anti-estrogens, demonstrating that a protein complex min a subset of breast cancer plays a role in chemotherapy resistance and metastasis-research that, in collaboration with other institutions, is currently in phase I clinical trial. Additional work included circulating biomarkers that predict the effect of breast cancer on the general well-being of a patient and a new patent application on how to treat specific subtypes of breast cancer. His group also established a culturing method to grow and genomically characterize primary tumors and metastasis at the individual level.
Dr. Nakshatri's work to identify biomarkers of disease progression is another example of how IUPUI faculty are TRANSLATING RESEARCH INTO PRACTICE.
Selected Publications in IUPUI ScholarWorks
With several research works contributed to IUPUI's free, open access repository, Dr. Nakshatri has made translational research knowledge available to professionals, researchers, students, and communities around the world.
Yang, R., Zhu, D., Kou, Q., Bhat-Nakshatri, P., Nakshatri, H., Wu, S., & Liu, X. (2017). A Spectrum Graph-Based Protein Sequence Filtering Algorithm for Proteoform Identification by Top-Down Mass Spectrometry. Proceedings. IEEE International Conference on Bioinformatics and Biomedicine, 2017, 222–229. http://hdl.handle.net/1805/18718
Beg, F., Wang, R., Saeed, Z., Devaraj, S., Masoor, K., & Nakshatri, H. (2017). Inflammation-associated microRNA changes in circulating exosomes of heart failure patients. BMC Research Notes, 10. http://hdl.handle.net/1805/16963
Bhat-Nakshatri, P., Goswami, C. P., Badve, S., Magnani, L., Lupien, M., & Nakshatri, H. (2016). Molecular Insights of Pathways Resulting From Two Common PIK3CA Mutations in Breast Cancer. Cancer Research, canres.3174.2015. http://hdl.handle.net/1805/11964
Courtney Finnearty, Ayesha Shajahan-Haq, Hari Nakshatri, and George E. Sandusky. 2016, April 8. Using TMAs (Tissue MicroArrays) to Evaluate GLS, GLUL, and CAV 1 Immunostaining in Breast Cancer. Poster session presented at IUPUI Research Day 2016, Indianapolis, Indiana. http://hdl.handle.net/1805/10033
Welch, D. R., Antalis, T. M., Burnstein, K., Vona-Davis, L., Jensen, R. A., Nakshatri, H., … Weiner, G. J. (2015). Essential Components of Cancer Education. Cancer Research, 75(24), 5202–5205. http://hdl.handle.net/1805/13049
Nakshatri, H., Appaiah, H. N., Anjanappa, M., Gilley, D., Tanaka, H., Badve, S., … Bhat-Nakshatri, P. (2015). NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death & Disease, 6(1), e1608–. http://hdl.handle.net/1805/11437
Burnett, R. M., Craven, K. E., Krishnamurthy, P., Goswami, C. P., Badve, S., Crooks, P., … Nakshatri, H. (2015). Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget, 6(14), 12682–12696. http://hdl.handle.net/1805/10369
Nakshatri, H., Anjanappa, M., & Bhat-Nakshatri, P. (2015). Ethnicity-Dependent and -Independent Heterogeneity in Healthy Normal Breast Hierarchy Impacts Tumor Characterization. Scientific Reports, 5, 13526. http://hdl.handle.net/1805/8519
Goswami, C. P., & Nakshatri, H. (2014). PROGgeneV2: enhancements on the existing database. BMC Cancer, 14, 970. http://hdl.handle.net/1805/9627
Chen, D., Goswami, C. P., Burnett, R. M., Anjanappa, M., Bhat-Nakshatri, P., Muller, W., & Nakshatri, H. (2014). Cancer impacts microRNA expression, release and function in cardiac and skeletal muscle. Cancer Research, 74(16), 4270–4281. http://hdl.handle.net/1805/9327
Bhat-Nakshatri, P., Goswami, C. P., Badve, S., Sledge, G. W., & Nakshatri, H. (2013). Identification of FDA-approved Drugs Targeting Breast Cancer Stem Cells Along With Biomarkers of Sensitivity. Scientific Reports, 3. http://hdl.handle.net/1805/18722
Chen, D., Bhat-Nakshatri, P., Goswami, C., Badve, S., & Nakshatri, H. (2013). ANTXR1, a stem cell enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer. Cancer Research, 73(18), 5821–5833. http://hdl.handle.net/1805/18725
Goswami, C. P., & Nakshatri, H. (2013). PROGgene: gene expression based survival analysis web application for multiple cancers. Journal of Clinical Bioinformatics, 3, 22. http://hdl.handle.net/1805/18721
Nakshatri, Harikrishna, George W. Sledge Jr., Sunil Badve, Casey Bales, David P. Gilley, Chirayu Goswami, Clark D. Wells, Theresa Guise, and Kim W. Ziner. (2013, April 5). THE INDIANA CENTER FOR BREAST CANCER RESEARCH: PROGRESS REPORT. Poster session presented at IUPUI Research Day 2013, Indianapolis, Indiana. http://hdl.handle.net/1805/7255
George W. Sledge Jr., Sunil Badve, Casey Bales, Erin M. Gill, David P. Gilley, Chirayu Goswami, Clark D. Wells, Kim W. Ziner, and Harikrishna Nakshatri. (2012, April 13). The Indiana Center for Breast Cancer Research: Progress towards a SPORE Proposal. Poster session presented at IUPUI Research Day 2012, Indianapolis, Indiana. http://hdl.handle.net/1805/8064
Badve, S., Collins, N. R., Bhat-Nakshatri, P., Turbin, D., Leung, S., Thorat, M., … Nakshatri, H. (2010). Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers. The American Journal of Pathology, 176(5), 2139–2149. http://hdl.handle.net/1805/18747
McCune, K., Bhat-Nakshatri, P., Thorat, M. A., Nephew, K. P., Badve, S., & Nakshatri, H. (2010). Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet. Cancer Research, 70(2), 685–696. http://hdl.handle.net/1805/18748
Nakshatri, H. (2010). Radiation resistance in breast cancer: are CD44+/CD24-/proteosomelow/PKH26+ cells to blame? Breast Cancer Research : BCR, 12(2), 105. http://hdl.handle.net/1805/18746
Bhat-Nakshatri, P., Wang, G., Collins, N. R., Thomson, M. J., Geistlinger, T. R., Carroll, J. S., … Nakshatri, H. (2009). Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Research, 37(14), 4850–4861. http://hdl.handle.net/1805/18750
Bhat-Nakshatri, P., Wang, G., Appaiah, H., Luktuke, N., Carroll, J. S., Geistlinger, T. R., … Nakshatri, H. (2008). AKT Alters Genome-Wide Estrogen Receptor α Binding and Impacts Estrogen Signaling in Breast Cancer. Molecular and Cellular Biology, 28(24), 7487–7503. http://hdl.handle.net/1805/18751